Ca<sup>2+</sup> Activated K<sup>+</sup> Channel K<sub>ca</sub>3.1 as a Determinant of Gastric Acid Secretion
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چکیده
منابع مشابه
Luminal K+: A Critical Determinant of Gastric Acid Secretion
No other tissue in the human body builds higher concentration gradients for H+ than the stomach mucosa by forming gastric acid. Parietal cells pump protons into the luminal space of gastric glands leading to a 1-million-fold enrichment of H+ in the gastric juice. The identification (18, 19, 23), characterization (42, 60), and cloning (11, 68) of the luminal H+/K+ exchanging ATPase as a molecula...
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PURPOSE OF REVIEW The present review summarizes the past year's literature, both clinical and basic science, regarding neuroendocrine and intracellular regulation of gastric acid secretion and proper use of antisecretory medications. RECENT FINDINGS Gastric acid kills microorganisms, modulates the gut microbiome, assists in digestion of protein, and facilitates absorption of iron, calcium, an...
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It is well established that the esophageal distention (ED) leads to gastric relaxation, partly by vago-vagal reflex, but till now, the effect of ED on gastric acid secretion has not been investigated. The aim of this study was to investigate the effect of ED on basal and stimulated gastric acid secretion. Methods: Adult male Wistar rats (200-240 g) were deprived of food but not the water 24 h b...
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Introduction: Recently, hydrogen sulfide has been introduced as the third gas that acts as a transmitter. It has many physiological and pharmacological roles in the human body. The aim of the present study was to investigate the effect of exogenously administered and endogenously produced H2S on the basal and distention-induced gastric acid secretion in rats. Methods: Forty-nine male Wistar...
متن کاملGastric Acid Secretion from Parietal Cells Is Mediated by a Ca2+ Efflux Channel in the Tubulovesicle.
Gastric acid secretion by parietal cells requires trafficking and exocytosis of H/K-ATPase-rich tubulovesicles (TVs) toward apical membranes in response to histamine stimulation via cyclic AMP elevation. Here, we found that TRPML1 (ML1), a protein that is mutated in type IV mucolipidosis (ML-IV), is a tubulovesicular channel essential for TV exocytosis and acid secretion. Whereas ML-IV patients...
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ژورنال
عنوان ژورنال: Cellular Physiology and Biochemistry
سال: 2011
ISSN: 1421-9778,1015-8987
DOI: 10.1159/000329981